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As you may have heard by now, Microsoft along with Addis Ababa University have developed the language interface for Ethiopia’s official language and is now available for install. We have created a step- by- step guide on how to install the pack and configure your Windows Vista to display menu and commands in Amharic. The language pack is available for Windows 7, but we don’t have the download location and will let you know as soon as we know about it. In less than 3. 0 minutes, you can install the LIP and have your PC speak with you in Amharic ? which has its own script. Here is how to get started. Get the language pack from microsoft. And follow our easy to follow - we hope installation guide (PDF)ምልከታየWindows Vista የቋንቋ ኢንተርፌስ ጥቅል (Language Interface Pack) በሰፊው …Click here to continue reading about this article at Nazret. I hope that these two posts will give you a good guide to using Amharic on your computer. My next blog entry will be on Thursday March 2. Mullkam Samint! Related. 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The chair of the county association’s county match committee is optimistic that this year’s South & West Counties Championship title- winning feat, which came hard on the heels of an Inter- County Tournament triumph at their Oaklands Park base in Almondsbury against league rivals Dorset, Somerset, Wiltshire and Devon, can be repeated in 2. Beating Devon as we did (1. Sue enthused.“It was hard finishing up as runners- up by only two points to them last season and I well recall our captain Ashleigh Parsons turning to me and saying, ‘We’re going to be going for the double next year.“It was a view echoed by the other players too and as we’ve just seen, they’ve gone on and achieved it this time and the managers, Steve Lilley and Calum Wands, and all the players have been brilliant.”Sue said of the back- up the team had been given: “It’s not just about on the pitch but off it too and it’s a credit to everyone behind the scenes that our players have come so far.“We also won the Inter- County Tournament at the Gloucestershire FA in June, which is a one- day competition involving our South West league compatriots organised and instigated initially a few years ago by Alexis Lunn- Gadd, who is women’s football development officer at the GFA.“Again we went through the day unbeaten but it’s great to see how much the other counties who come down to Oaklands Park to take part love the tournament and the facilities at the GFA.“I’m sure they’re all looking forward to next season every bit as much as we are as we look to try and keep our title and go for another double.”Trophy and medals will be handed to Gloucestershire Women by league chairman David Grainge at a presentation evening at Chipping Sodbury Town FC on Thursday, September 2. Stars of the world stage: Gloucestershire greats Blackwell and Rutter hit CP heights. TWO true stars of Gloucestershire football have been celebrating an “amazing experience” in Argentina, even if their hopes of ultimate success were denied them, reports Simon Parkinson. James Blackwell, a full- back with County League team Kingswood, and Jack Rutter, a one- time Birmingham City prodigy who performs as an attacking midfielder with Hellenic League Lydney Town, have been featuring for England Cerebral Palsy (CP) team in the seven- a- side CP World Championships. The duo were part of a national side taking the group stages by storm with thumping 1. Japan, Venezuela and Holland respectively, before bouncing back from a goal down to overcome USA 2- 1 in the last eight and set up a dream semi- final appearance against a strong Iran outfit. Rutter’s surging run and unerring right- foot finish into the bottom corner from the edge of the box in that quarters showdown with the States was enough to see them to that last- four tie in the picturesque town of San Luis in central Argentina, an “unforgettable experience” according to Blackwell, despite the disappointment of a 3- 1 defeat. The 3. 1- year- old enthused: “It’s the first time we as a country have ever reached the semis at these championships and it’s been an amazing experience.“The setting in San Luis is stunning and playing in traditional South American stadiums against the world’s best has been wonderful and memorable.“We even visited a local school which was a very humbling experience as it seemed to mean so much for the kids there to meet us.“As a nation we’ve shown how far we’ve come to be challenging for a top- four finish to such a prestigious tournament against professional, full- time athletes.”Blackwell was born with a condition which affects the movement and flexibility of muscles down the entire left side of his body. His Cerebral Palsy (CP) diagnosis as a youngster came with a stark warning to his devoted parents that their son might never walk. In more recent times he suffered what was deemed by specialists as “life- threatening injuries” in a County League Cup tie against Patchway Town when a heavy fall left him with a broken neck and spinal cord damage. Blackwell and his county compatriot Rutter have both battled through physical and mental traumas to find themselves on the cusp of bronze medal joy, as a third- place play- off tussle with Russia was due to be confronted on Saturday, September 2. I’ve played in every game in the tournament so far, mainly from the bench which is partly down to tactics,” Blackwell explained. I’m looked at to come on and help see games out or to try and add more goals as it’s very demanding compared with 1. But I’ve scored a goal at the tournament and set a few up so I’m satisfied enough!” As for Rutter, he continues to perform at a high level of standard semi- pro football with Lydney in the Hellenic Premier, despite having suffered brain damage and permanent loss of hearing in his right ear after being set upon in an unprovoked attack in Gloucester one night as an 1. The player has skippered England CP for the past four years and he glowed: “It’s been a brilliant tournament in a great location and the hotel we are in is unbelievable. And stadiums are of an okay standard too.“We got off to a flyer in the group stages and we showed great character to come back from 1- 0 down against the US, who are a well drilled, strong, quick and fit side, and win through.“Iran took their chances in the semi- final and we didn’t, simple as. But the progression is there for all to see,” insisted the UEFA B licensed coach, who is a mentor for the Dame Kelly Holmes Trust and head of disability football for Mc. Donald’s’ Play Better programme, not to mention a coach at University of Gloucestershire. More about Jack Rutter can be found at: jackrutterskillsschool. Lilley so proud as Gloucestershire FA Women bounce back to claim prized double STEVE Lilley reflected on a superb season for Gloucestershire FA Women on the inter- county representative stage and glowed: “Our players should be immensely proud of what they’ve achieved”. An 1. 1- 0 victory over Devon at Oaklands Park assured the gallant Glos girls the 2. South & West Counties Championship crown at the expense of opponents who, had they instead prevailed on the evening, might yet have snatched the title from under the noses of their hosts with a game in hand at Somerset next month to fuel their chances. The outcome was all the more remarkable as only 1. 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Bortezomib (VELCADE®) is a proteasome inhibitor that not only targets the myeloma cell, but also acts in the bone marrow micro-environment, inhibiting the binding of. Bcl-2 based cancer medicine, mechanism of action, and clinical trial status. The introduction of novel agents thalidomide, lenalidomide, and the proteasome inhibitor bortezomib, has dramatically improved the outcome of multiple myeloma and. ![]() · Induction chemotherapy before autologous stem cell transplantation for symptomatic plasma cell myeloma – does it matter? Bcl- 2. Bcl- 2. Bcl- 2(1. Proteins of the Bcl- 2 family have either. Members of the Bcl- 2 protein include three sub- groups of proteins that promote cell survival (e. Bcl- 2 and Bcl- x. L), initiate cell. Bim, Puma, and Bid), or activate the effector pathways of apoptosis (Bax, Bak).(4) The two isoforms of Bcl- 2, 1. G5. M and 1. G5. O/1. GJH, exhibit. similar fold, but the disparate binding to BAD and BAK proteins, suggesting different anti- apoptotic activity.(1) The intrinsic apoptotic pathway involves. Bcl- 2 family of proteins- mediated alterations in mitochondrial membrane integrity and potential in response to cellular insults or other stress signals.(5). Several Bcl- 2 family members, including Bcl- 2 and Bak, reside not only on mitochondria but also on the ER/nuclear envelope, where they may regulate cytosolic. Ca. 2+ levels.(6) The pro- apoptotic BCL- 2 members are divided into the effector proteins and the BH3- only proteins. It is controversial whether some BH3- domain. Bim or t. Bid) directly activate multidomain pro- apoptotic proteins (e. Bax and Bak) or act via inhibition of those anti- apoptotic Bcl- 2 proteins. Bcl- 2, Bcl- XL, Bcl- w, Mcl- 1, Bfl. A- 1, and Bcl- B) that stabilize pro- apoptotic proteins.(7) The BH3- only proteins sense and relay stress signals, but. Bax or Bak. The BH3- only proteins appear to activate Bax and Bak indirectly, by engaging and neutralizing their pro- survival. Bax and Bak from permeabilizing mitochondria.(6) The effector proteins BAK and BAX were originally described to contain. BH1- 3; however, structure- based alignment of globular BCL- 2 family proteins revealed a conserved BH4 motif. The proapoptotic BCL- 2 members are divided. BH3- only proteins. The effector proteins BAK and BAX were originally described to contain only BH1- 3; however. BCL- 2 family proteins revealed a conserved BH4 motif.(8) Upon activation, BAK and BAX homo- oligomerize into proteolipid. OMM to promote MOMP There is a potential third effector molecule, BCL- 2- related ovarian killer (BOK), but no biochemical evidence supports a. BAK or BAX.(9). In most cell types, caspase- 8 catalyzes the cleavage of the pro- apoptotic BH3- only protein Bid into its truncated form, t. Bid. BH- 3 only members of the Bcl- 2 family exclusively engage anti- apoptotic members of the family (Bcl- 2, Bcl- x. L), allowing Bak and Bax to translocate to the outer mitochondrial membrane, thus permeabilizing it and facilitating release of pro- apoptotic proteins such as Cytc and Smac/DIABLO, an antagonist of IAPs.(1. PUMA is a BH3- only protein that binds and inhibits all of the anti- apoptotic BCL- 2 proteins. It is a direct transcriptional target of p. FOXO3a under conditions of growth factor deprivation. PUMA may also activate BAX and BAK, although it has been shown to promote MOMP predominantly through displacement of other proteins with this function from anti- apoptotic BCL- 2 proteins.(1. The BH3- only proteins sense and relay stress signals, but commitment to apoptosis requires Bax or Bak. The BH3- only proteins appear to activate Bax and Bak indirectly, by engaging and neutralizing their pro- survival relatives, which otherwise constrain Bax and Bak from permeabilizing mitochondria.(6) It is controversial whether some BH3- domain proteins (Bim or t. Bid) directly activate multidomain pro- apoptotic proteins (e. Bax and Bak) or act via inhibition of those anti- apoptotic Bcl- 2 proteins (Bcl- 2, Bcl- XL, Bcl- w, Mcl- 1, Bfl. A- 1, and Bcl- B) that stabilize pro- apoptotic proteins.(7). Cancer cells may escape from apoptosis in response to various stimuli, such as chemotherapy and radiotherapy, by increasing anti- apoptotic proteins of Bcl- 2 protein family, including Bcl- 2, Bcl- x. L, Bcl- w, Mcl- 1 and Bfl- 1.(3) Loss of PUMA accelerates Myc- induced lymphomagenesis. Importantly, in a survey of a large number of human tumors of different types, deletion of PUMA was found to be one of the most common copy- number abnormalities.(1. Clinical studies on ABT- 2. AT- 1. 01 are currently ongoing and whether these compounds can find their way into routine clinical use will depend not only on efficacy but also on manageable, acceptable toxicities. Thrombocytopenia, for example, may limit the value of ABT- 2. Bcl- 2 suppression remain to be determined.(5). Drugs/Indications. News. References. Tumor. Suppress. LEC. Available from: http: //biochemistry. Tumor. Suppress. LEC. Brunelle JK LA. Control of mitochondrial apoptosis by the Bcl- 2 family. J Cell Sci. 2. 00. Pt 4): 4. 37- 4. 1. PMCID: 1. 91. 93. Gul O BH, Kutuk O. Apoptotic blocks and chemotherapy resistance: strategies to identify Bcl- 2 protein signatures. Brief Funct Genomic Proteomic. PMCID: 1. 82. 83. Kelly PN SA. The role of Bcl- 2 and its pro- survival relatives in tumourigenesis and cancer therapy. Cell Death Differ. PMCID: 2. 14. 15. Azmi AS WZ, Philip PA, Mohammad RM, Sarkar FH. Emerging Bcl- 2 inhibitors for the treatment of cancer. Expert Opin Emerg Drugs. PMCID: 2. 08. 12. Adams JM CS. Bcl- 2- regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol. PMCID: 1. 76. 29. Kang MH RC. Bcl- 2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 2. PMCID: 1. 92. 28. Kvansakul M YH, Fairlie WD, Czabotar PE, Fischer SF, Perugini MA, Huang DC, Colman PM. Vaccinia virus anti- apoptotic F1. L is a novel Bcl- 2- like domain- swapped dimer that binds a highly selective subset of BH3- containing death ligands. Cell Death Differ. PMCID: 1. 85. 51. Chipuk JE MT, Llambi F, Parsons MJ, Green DR. The BCL- 2 family reunion. Mol Cell. 2. 01. 0; 3. PMCID: 2. 01. 59. Schaller MD. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. Journal of Cell Science. Llambi F GD. Apoptosis and oncogenesis: give and take in the BCL- 2 family. Curr Opin Genet Dev. PMCID: 2. 12. 36. Tilly JL. Commuting the death sentence: how oocytes strive to survive. Nature Reviews Molecular Cell Biology. Aim: The aim of this study was to investigate the effects of punicalagin, a polyphenol isolated from Punica granatum, on human A2. Methods: The viability of human A2. Cell Counting Kit- 8 assay. Cell cycle was detected with flow cytometry analysis. The protein expression levels of Bcl- 2, Bax, β- catenin, cyclin D1, survivin, tissue inhibitor of metalloproteinase (TIMP)- 2, and TIMP- 3 were measured using Western blot analysis. Matrix metalloproteinase (MMP)- 2 and MMP- 9 activity was determined with gelatin zymography. Wound healing assay was used to determine cell migration. Results: Punicalagin inhibited the cell viability of A2. A2. 78. 0 cells was arrested in G1/S phase transition. The treatment also induced apoptosis as shown by the up- regulation of Bax and down- regulation of Bcl- 2. On the other hand, punicalagin treatment increased the expressions of TIMP- 2 and TIMP- 3, decreased the activities of MMP- 2 and MMP- 9, and inhibited cell migration. In addition, the β- catenin pathway was suppressed as shown by the down- regulations of β- catenin and its downstream factors including cyclin D1 and survivin. Conclusions: Punicalagin may have cancer- chemopreventive as well as cancer- chemotherapeutic effects against human ovarian cancer in humans through the inhibition of β- catenin signaling pathway. Restoration of p. Identification of p. PRIMA- 1 holds promise for effective new anticancer therapies. Here, we investigated the effects of small molecule PRIMA- 1 on cell viability and expression of p. NB4 cell line. Our results showed that PRIMA- 1 had antileukemic properties in acute promyelocytic leukemia- derived NB4 cells. PRIMA- 1- triggered apoptosis in a dose- dependent and time- dependent manner as indicated by the MTT assay and annexin- V staining. Apoptosis induction by PRIMA- 1 was associated with caspase- 9, caspase- 7 activation and PARP cleavage. PRIMA- 1 treatment and real- time PCR analysis of proapoptotic p. Bax and Noxa. Western blot analysis showed that I[kappa]B[alpha] phosphorylation and its degradation were inhibited by PRIMA- 1. Moreover, protein expression of nuclear factor- [kappa]B- regulated antiapoptotic (Bcl- 2 and XIAP) and proliferative (c- Myc) gene products was decreased. Importantly, PRIMA- 1 did not show any significant apoptotic effect in normal human peripheral blood mononuclear cells. These in- vitro studies imply that p. Copyright (C) 2. 01. Wolters Kluwer Health, Inc. All rights reserved. CD3. 7 (tetraspanin TSPAN2. B- cell surface antigen widely expressed on mature B- cells. Join Our Community! Top News Blogger Template is a Clean, simple and elegant Blogger Theme suitable for any kind of blog, personal, fashion, food, travel, photography, publishing or tutorial blog sites. ![]() It is perfect for News Blogger. The theme is very flexible and super easy to use. It is packed with tons of features and custom widgets. 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